Gly - Pro - Glu is a weak NMDA receptor agonist
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چکیده
The IGF-derived tripeptide Gly-Pro-Glu is a weak NMDA receptor agonist 1 2 Authors: Christopher E Vaaga, Kenneth R Tovar and Gary L Westbrook 3 4 Author addresses: 5 Neuroscience Graduate Program, Oregon Health and Science University, Portland, Oregon, 6 USA 7 Vollum Institute, Oregon Health and Science University, Portland, Oregon, USA 8 9 Running head: GPE action on NMDA receptors 10 11 Author Contributions: CEV, KRT and GLW designed research; CEV and KRT performed 12 experiments and analyzed data. CEV and GLW wrote the manuscript. 13 14 Corresponding Author: Christopher E Vaaga, Vollum Institute, L474; Oregon Health and 15 Science University, 3181 SW Sam Jackson Park Road; Portland, OR 97239 USA; Email: 16 [email protected]; Tel: (503) 494-5436 17 18 19 20 Articles in PresS. J Neurophysiol (June 18, 2014). doi:10.1152/jn.00290.2014
منابع مشابه
The IGF-derived tripeptide Gly-Pro-Glu is a weak NMDA receptor agonist.
Glutamate acts as the universal agonist at ionotropic glutamate receptors in part because of its high degree of conformational flexibility. Other amino acids and small peptides, however, can activate N-methyl-d-aspartate (NMDA) receptors, albeit usually with lower affinity and efficacy. Here, we examined the action of glycine-proline-glutamate (GPE), a naturally occurring tripeptide formed in t...
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تاریخ انتشار 2014